Slows Gastrointestinal Transit in Rats
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چکیده
R.J. KOSLO, J.L. VAUGHT, A. COWAN, D.E. G M E R E K and F. PORRECA, lntrathecal morphine slows gastrointestinal transit in rats, European J. Pharmacol. 119 (1985) 243-246. Intrathecal (i.th.) (by direct lumbar puncture) and intraperitoneal (i.p.) administration of morphine (30-100/~g/rat) caused a dose-related inhibition of gastrointestinal transit in the rat. Pretreatment with i.th. naloxone (5/tg at 5 min) reversed the effects of i.th., but not i.p., morphine. These results suggest that the spinal cord appears to be a target site for the inhibitory effects of morphine on gastrointestinal transit in the rat.
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تاریخ انتشار 2002